Reference of 113100-53-1, A common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1-methyl- 3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (400 mg, 2.06 mmol) in THF (6 mL) was added BH3.DMS (0.412 mL, 4.12 mmol) dropwise over 1 mm at 0 C under nitrogen. Thereaction was stirred at 0 C for 0.5 h, at 20 C for 0.5 h, and at 80 C for 3 h. Then the reaction was quenched with MeOH (20 mL) at 0 C, and the mixture was concentrated under reduced pressure to give the title compound, which was used directly in the next step without further purification. MS (ESI) m/z: 181.0 [M+Hj 1H NMR (400MHz, DMSO-d6) 3 = 7.81 (s, 1H), 5.12 (t, J=S.3 Hz, 1H), 4.40 (d, J5.1 Hz, 2H), 3.88 (s, 3H).
The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.