Adding a certain compound to certain chemical reactions, such as: 16034-48-3, name is 1-Pyrazoleacetic Acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16034-48-3, SDS of cas: 16034-48-3
To a solution of 1 .76 g of Pyrazol-1 -yl-acetic acid in 20 ml of dry DMF 2.09 g of HOAT, 3.75 g of EDC and 6.9 ml of DIPEA were added at 0C. After 30 min 3.3 g of 3-amino-4-(1 -ethyl-propylamino)-benzoic acid methyl ester were added and the reaction was stirred at rt for 16 h. The reaction was then poured into water and extracted with ethyl acetate three times. The combined organic phases were washed with saturated aqueous sodium bicarbonate solution and brine, dried over magnesium sulphate and concentrated. The crude product was purified by precipitation from heptane to yield 2.28 g (47 %) of 4-(1 -Ethyl-propylamino)-3-(2- pyrazol-1 -yl-acetylamino)-benzoic acid methyl ester. C 8H24N4O3 (344.42), LCMS (method 8_1_1 ): Rt = 0.85 min, m/z= 345.15 [M+H]+
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