Reference of 139756-02-8, These common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of Bh, Step 7: 4-amino-i -methyl-3-propyl- 1 H-pyrazole-5-carboxamide (1 eq) and 4-chlorobenzaldehyde (1.1 eq) were suspended in ethanol 5 ml and the mixtureheated at 70 C for 1.5 hours after conformation of forming of imine by TLC. Added CuCl2 (3 eq) and the reaction mixture heated at 75 C under 02 for 1 hours. After completion of the reaction, the ethanol was removed under vacuum. Then workup with ethyl acetate and water. Separate the organic layer and Water layer re-extracted with 2x 25 ml ethyl acetate. The combined organic layers are washed with brine solution,concentrated under vacuum. The residue was purified by column chromatography on silica the desired product Bh as a white solid; yield 90%. ?H NMR (200 MHz CDC13):6; 1 l.51(s 1H), 8.l(d J=8.6Hz 2H), 7.49(d J8.611z 2H), 4.3(s 31-I), 2.93(t J=7.5Hz 2H), 1.96(m 2H), 1.03(t J= 7.5Hz 3H). MASS: ES [M + H] . 303.09; Elemental anal. calcd. for C15H,5C1N4O ; C, 59.51; H, 4.99; Cl, 11.71; N, 18.51; 0, 5.28; found C,59.44; H, 5.01; Cl, 11.72; N, 18.53; 0, 5.30
The synthetic route of 139756-02-8 has been constantly updated, and we look forward to future research findings.