These common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Amino-5-phenylpyrazole
To a solution of compound compound 5 (300 mg, 1.83 mmol) in THF (20 mL) was added a .solution of 3-amino-5-phen.ylpyrazole {291 mg, 1.83 mmol) and DlPEA (0.32 mL, 1.83 mmol) in TlIF (8 m_) dropwise at 0 C. After addition, the mixture was stirred at 0 C for additional 60 minutes. TLC was checked and the starting materials were consumed, l-mcthylpipcrazine (0.41 mg. 3.66 mmol) and DlPEA (0.32 mL. 1.83 mmol) was added to the above reaction flak at room temperature. The mixture was stirred at room temperature for overnight. After concentrated to Ethyl acetate (50 ml) and saturated KaHCCh in water were added to the flask. The aq was removed by pipette and silica gel was added. After removal of the organic solvents, the crude product was purified by flash column chromatography on silica gel using DCM/MeOH: 90/10 v/v as eluent to provide compound 15 as white solids (570 mg, 89%). 1H NMR (400 MlIz. DMSOd6) delta 12.72 (br. 111). 9.90 (br, I H), 7.69 ( m. 211) . 7.44 (m, 3H), 6.90 (br. 111). 3.75 (br, 4H), 2.33 (br. 411). 2.19 (overlapped 2 Me. 611); ESl-MS: calcd for(C18II22N8) 350, found 351 (Ml T).
The synthetic route of 3-Amino-5-phenylpyrazole has been constantly updated, and we look forward to future research findings.