Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15878-00-9, name is 4-Chloro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 15878-00-9
Example 94 trans-2′-tert-Butyl-4-chloro-2’H-[1,3′]bipyrazolyl-4′-carboxylic acid (5-acetylamino-adamantan-2-yl)-amide Sodium hydride (60% in oil; 220 mg, 5.5 mmol) was added slowly to a solution of 4-chloro-pyrazole (710 mg, 6.9 mmol) in dry DMF (40 mL) at 0 C. in an ice-water bath. The mixture was stirred under argon for 10 minutes and the mixture was then heated to 40 C. for 2 hrs. trans-1-tert-Butyl-5-chloro-1H-pyrazole-4-carboxylic acid (5-acetylamino-adamantan-2-yl)-amide (270 mg, 0.69 mmol) was added and the mixture was heated at 110 C. overnight for 2 days and then cooled. The solvent was removed in vacuo. The resulting mixture was diluted with water and extracted with ethyl acetate (2X). The organic layers were combined and dried with magnesium sulfate, filtered and concentrated in vacuo. The solid was slurried in ether and filtered and dried under high vacuum to afford trans-2′-tert-butyl-4-chloro-2’H-[1,3′]bipyrazolyl-4′-carboxylic acid (5-acetylamino-adamantan-2-yl)-amide as a white solid (237 mg, 74%); ES(+)-HRMS m/z calcd for C23H31ClN6O2 (M+H) 459.2270, found 459.2268.
According to the analysis of related databases, 15878-00-9, the application of this compound in the production field has become more and more popular.