Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2075-45-8, name is 4-Bromo-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 2075-45-8
To a solution of 466 4-bromo-1H-pyrazole 51b (146 mg, 1 mmol) in 20 dichloromethane was added successively with 153 triethylamine (303 mg, 3 mmol) and 467 di-tert-butyl dicarbonate (327 mg, 1.5 mmol), and the mixture was stirred at room temperature for 3 h. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate=100/1 to 10/1) to give the target 468 product tert-butyl 4-bromo-1H-pyrazole-1-carboxylate 51c (150 mg, white solid). Yield: 61%. MS m/z (ESI): 247[M+1]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.