Discovery of 5334-41-8

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.

5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H6N4

Example 1.1.: 5-amino-1-methyl-1H-pyrazole-4-carboxamide (2) 12.2 g (100 mmol) of 5-amino-1-methyl-1H-pyrazole-4-carbonitrile, 1 (Commercial supplier: BIONET-INTER) are dissolved in 50 mL of conc. sulfuric acid and stirred at RT for 3 h. The reaction mixture is cooled to 0-5 C and neutralized at that temperature by addition of aqueous ammonia. The water phase is extracted with chloroform, the solvent is evaporated and the residue crystallized from water to yield the title compound.

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.