Reference of 127107-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
2-(6-((2,5-dichloropyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)isoindoline-1,3-dione (370.0 mg, 0.88 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (354.2 mg, 2.65 mmol) were dissolved in n- BuOH (10 mL) and DIPEA (683.1 mg, 5.29 mmol). The reaction mixture was stirred at 150 C overnight and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (MeOH / CH2Cl2 (v / v) = 1/30) to give the title compound as a red solid (140.0 mg, 33.1%).
The synthetic route of 1-Methyl-1H-pyrazol-4-amine hydrochloride has been constantly updated, and we look forward to future research findings.