Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Diethyl 3,5-pyrazoledicarboxylate
NaOH (3.53 g, 88 mmol) was added to a solution of diethyl 1H-pyrazole-3,5- dicarboxylate (5.35 g, 25.2 mmol) in acetonitrile (40 mL). After 30 mi 2- chloroethanamine hydrochloride (3.22 g, 27.7 mmol) and tetrabutylammonium hydrogen sulfate (0.43 g, 1.26 mmol) were added. The mixture was refluxed for 20 h. Aftercooled, conc. HC1 (5 mL) was added. The mixture was extracted with CH2C12, washed with brine. The combined organic layers were dried over Na2SO4, filtered and concentrated. Normal phase chromatography afforded Intermediate 138 (2.72 g, 52%) as a white solid. ?H NMR (500MHz, DMSO-d6) oe 8.39 (br s, 1H), 7.07 (s, 1H), 4.40 (dd, J6.7, 5.5 Hz, 2H), 4.27 (q, J7.2 Hz, 2H), 3.68 – 3.61 (m, 2H), 1.28 (t, J=7.0 Hz, 3H).LC-MS(ESI) m/z: 210.1 [M+H].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.