In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H8N2O3
To a stirred solution of methyl 5-hydroxy-2-methyl-pyrazole-3-carboxylate (0.3 g, 1.92mmol) in DCM (30 mL) at 0 C, Pyridine (0.18 g, 2.30 mmol) followed by Tf20 (0.59 g, 2.11mmol) was added dropwise. The reaction mixture was slowly warmed toRT and stirred for 2h (TLC indicated complete consumption of starting material). The reaction mixture wasslowly diluted with water (15 mL) and extracted with DCM (2 x 30 mL). The combinedorganic extracts were washed with brine (25 mL), dried over Na2S04 and concentrated underreduced pressure to afford methyl 2-methyl-5-(trifluoromethylsulfonyloxy)pyrazole-3-carboxylate (580 mg, 93% ), which was carried to the next step without further purification.LCMS: m/z: 289.4 [M+Ht.
The synthetic route of 52867-42-2 has been constantly updated, and we look forward to future research findings.