Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57097-81-1, name is 3-Bromo-5-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-5-methyl-1H-pyrazole
Step A: 5-(3-Bromo-5-methyl-lH-pyrazole-l -yl)-3-chloropyridazine To a solution of 3-bromo-5-methylpyrazole (0.4 g, 2.48 mmol) in DMF (5 mL) at room temperature was added KOtBu (0.279 g, 2.48 mmol) in one portion. To this mixture was added a solution of 3, 5-dichloropyridaine (0.37 g, 2.48 mmol) in DMF (5 mL). The reaction mixture was heated at 100 C for 1 h. The reaction mixture was cooled to room temperature, diluted with EtOAc (50 mL), washed with satd aq. NaHC03 (10 mL) and water (100 mL), the aqueous layers were separated and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water (100 mL), brine (100 mL), dried over Na2S04, filtered and concentrated. The crude solid was purified by PTLC (50% EtOAc in hexanes) to afford 5-(3-bromo-5- methyl-lH-pyrazole-l -yl)-3-chloropyridazine, as a white solid. LCMS calc. = 272.95; found – 272.88 (M+H)+.
The synthetic route of 57097-81-1 has been constantly updated, and we look forward to future research findings.