Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 211738-66-8, name is Methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 211738-66-8
To a solution of methyl 4-bromo- 1 -methyl- 1 H-pyrazole-3-carboxylate (p71 , 270. mg, 1.23 mmol) in DMF (8 mL), Cul (23.6 mg, 0.12 mmol) and Pd(Ph3)4 (142.4 mg, 0.12 mmol) were added and the mixture was degassed with nitrogen for 20min before adding tributyl(2-pyrimidinyl)stannane (0.5 mL, 1 .51 mmol). The reaction was stirred at 1 10 C for 4hrs. Reaction was cooled to RT and diluted with EtOAC and 1 M KF aq. solution. Phases were stirred at RT for 1 h and then separated. Organic layer was dried and solvent was removed under reduced pressure. Crude material was purified by FC on N H column (eluting from Cy to 60%EtOAc) to afford methyl 1 -methyl-4-(pyrimidin-2-yl)-1 H- pyrazole-3-carboxylate (p74, 90 mg, y= 33% yield) as white solid. MS (/T7/z): 219.0 [MH]+
The synthetic route of 211738-66-8 has been constantly updated, and we look forward to future research findings.