Reference of 42098-25-9,Some common heterocyclic compound, 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, molecular formula is C4H4ClN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A. tert-Butyl 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)-1,4-diazepane-1-carboxylate A mixture of 5-chloro-1-methyl-4-nitro-1H-pyrazole (0.403 g, 2.50 mmol) (prepared as described for Intermediate 1, Step A and B), tert-butyl 1,4-diazepane-1-carboxylate (0.500 g, 2.50 mmol) and DIPEA (0.791 mL, 4.54 mmol) in EtOH (2 mL) was heated under microwave irradiation at 130 C. for 1 h. The mixture was concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel using CombiFlash apparatus eluting with EtOAc/hexane (50-100%). The purification afforded 0.572 g (70.4% yield) of the sub-title compound as a yellow oil. LCMS calc. for C14H23N5O4Na (M+Na)+: m/z=348.2. found: 348.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1-methyl-4-nitro-1H-pyrazole, its application will become more common.