Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction was written by Yu, Guixue;Mason, Helen J.;Wu, Ximao;Wang, Jian;Chong, Saeho;Dorough, Gary;Henwood, Andrew;Pongrac, Ronald;Seliger, Laurie;He, Bin;Normandin, Diane;Adam, Leonard;Krupinski, John;Macor, John E.. And the article was included in Journal of Medicinal Chemistry in 2001.SDS of cas: 3528-58-3 This article mentions the following:
Eight potent PDE5 inhibitors represented by I are described which have a much improved PDE isoenzyme selectivity profile compared to sildenafil. I was at least equivalent to sildenafil in its functional PDE5 activity in rabbit corpus cavernosal tissue. The pharmacokinetic profile and adverse effects of I are also briefly discussed. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3SDS of cas: 3528-58-3).
1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 3528-58-3
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics