Reaction of β-aminoenones with hydrazine derivatives. Regioselective synthesis of pyrazoles was written by Alberola, A.;Andres, C.;Gonzalez Ortega, A.;Pedrosa, R.;Vicente, M.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1987.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:
The β-aminoenones, obtained by hydrogenation of isoxazoles (Raney Ni W-2), react with hydrazine derivatives giving pyrazoles in excellent yields. The reaction is general and regiospecific, and allows the preparation of pyrazoles with different functionality at C(4). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics