4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was written by Zohdi, Hussein;Rateb, Nora M.;Haikal, A. Z.. And the article was included in Molecules [online computer file] in 2001.COA of Formula: C4H3F3N2O This article mentions the following:
4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one (I) was synthesized by adding 5 mmol of 3-nitrobenzenediazonium chloride dropwise to a cold solution of 5-trifluoromethyl-2,4-dihydropyrazol-3-one (0.76 g, 5 mmol) in 25 mL of ethanol containing sodium acetate (0.82 g, 10 mol). The reaction mixture was stirred at room temperature for 3 h and the precipitated crude product was filtered, washed with water, dried and crystallized from ethanol to give 1.2 g (80%) of I as orange crystals. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0COA of Formula: C4H3F3N2O).
3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C4H3F3N2O
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics