Habraken, Clarisse L. et al. published their research in Recueil des Travaux Chimiques des Pays-Bas in 1966 | CAS: 5334-39-4

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.HPLC of Formula: 5334-39-4

Pyrazoles. I. Ionization constants and ultraviolet spectra of 4-nitropyrazoles was written by Habraken, Clarisse L.;Van Woerkom, P. C. M.;De Wind, H. W.;Kallenberg, C. G. M.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1966.HPLC of Formula: 5334-39-4 This article mentions the following:

Uv spectral data for 3(5)-methyl-4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 1-methyl-4-nitropyrazole, and 1,3,-5-trimethyl-4-nitropyrazole, and ionization constants for the 1st 2 compounds are tabulated. The data indicate the absence of a steric effect of ortho-methyl groups in 4-nitropyrazoles. The findings corroborate the investigations of Ehrlich (CA 55, 2237f). In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4HPLC of Formula: 5334-39-4).

3-Methyl-4-nitro-1H-pyrazole (cas: 5334-39-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.HPLC of Formula: 5334-39-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics