Selective method for the preparation of isomeric N-alkyl and N-aryl-3(5)-amino-5(3)-hydroxy-1H-pyrazole-1-carboxamides was written by Drummond, James T.;Johnson, Graham. And the article was included in Journal of Heterocyclic Chemistry in 1988.Recommanded Product: 934-48-5 This article mentions the following:
Aminoacylation of cyanohydrazides NCCHRCONHNH2 (R = H, Et, octyl, Ph, CHPh2) with 3,5-dimethyl-1H-pyrazole-1-carboxamide or isocyanates gave semicarbazides NCCHRCONHNHCONHR1 (I, R = Et, octyl, CHPh2, R1 = H; R = H, R1 = Me, CH2CH2Cl, C6H3Et2-2,6, C6H4OPh-4; R = R1 = H, Ph) in 23-96% yields. Cyclization of I with NaOH followed by HCl gave pyrazolecarboxamides II in 35-100% yields. Thermal isomerization of II in EtOAc gave isomeric pyrazolecarboxamides III. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 934-48-5).
3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Recommanded Product: 934-48-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics