Adding some certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6. 2458-26-6
Teri-butyl (R )-(2-(3-phenyl-1H-pyrazol- 1 -yl)propyl)carbamate 3-Phenyl-1 H-pyrazole (250 mg, 1 .73 mmol), cesium carbonate (5.65 g, 17.30 mmol) and (S)-1 -((ieri-butoxycarbonyl)amino)propan-2-yl methanesulfonate (876 mg, 3.46 mmol) were combined in anhydrous N,N- dimethylformamide (10 ml). The resulting suspension was heated to 50 C and the progress of the reaction was monitored by TLC. Once the reaction was complete (~ 18 h) the reaction mixture was quenched by addition of water and the product was extracted with ethyl acetate three times. The organic layers were combined and washed with a saturated aqueous solution of sodium chloride. All of the volatiles were removed in vacuo. The crude material was purified by column chromatography, eluting 5-10% ethyl acetate/petroleum spirits to give the title compound as a colourless solid (60 mg, 12%). LRMS [M+H]+ 302.2 m/z; HRMS [M+H]+ 302.1863 m/z, found 302.1867 m/z; 1 H NMR (400 MHz, CDCI3) delta 7.85 – 7.72 (m, 2H), 7.41 – 7.33 (m, 3H), 7.31 – 7.25 (m, 1 H), 6.54 (d, J = 2.3 Hz, 1 H), 5.05 (d, J = 1 .1 Hz, 1 H), 4.26 (dd, J = 13.8, 4.5 Hz, 1 H), 4.21 – 4.10 (m, 1 H), 4.05 (dd, J= 12.6, 6.7 Hz, 1 H), 1 .41 (s, 9H), 1 .12 (d, J = 6.8 Hz, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Phenyl-1H-pyrazole.