1134-50-5, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.
General procedure: Example 1-103 1-Phenyl-1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-ylmethyl]-amide A mixture of 3-(aminomethyl)-7-fluoro-1-(2-fluorophenyl)quinolin-4(1H)-one (intermediate H) (50 mg, 0.175 mmol), 1 -phenyl- 1H-pyrazole-4-carboxylic acid (66 mg, 0.349 mmol), bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBrOP) (112 mg, 0.24 mmol), triethylamine (53 mg, 0.524 mmol), and DMF (3 mL) was stirred at room temperature overnight. The crude material was purified by flash chromatography (12 g silica gel eluting with 100% hexanes ramped to 70% ethyl acetate in hexanes). The product 1 -phenyl- 1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fiuoro-phenyl)-4-oxo-1,4- dihydro-quinolin-3-ylmethyl]-amide (46 mg, 58%) was obtained as an off-white solid. MS calcd. for C22H14CIF2N3O2 [(M+H)+] 426.1, obsd. 426.1.
The chemical industry reduces the impact on the environment during synthesis 1-Phenyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.