Nam, Mina published the artcileDiscovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid, the publication is European Journal of Medicinal Chemistry (2015), 245-258, database is CAplus and MEDLINE.
Metabotropic glutamate receptor 1 (mGluR1) was a prime target for drug discovery due to its heavy involvement in various brain disorders. Recent studies suggested that mGluR1 is associated with chronic pain and can serve as a promising target for the treatment of neuropathic pain. In an effort to develop a novel mGluR1 antagonist, the authors designed and synthesized a library of compounds with tetrahydrothieno[2,3-c]pyridine scaffold. Among these compounds, compound 2-(Benzylamino)-6-(3-methyl-1H-pyrazole-5-carbonyl)4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile and 2-(Benzylamino)-6-(4-fluorobenzoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile showed excellent antagonistic activity in vitro and demonstrated pain-suppressing activity in animal models of pain. Both compounds were orally active, and compound 2-(Benzylamino)-6-(3-methyl-1H-pyrazole-5-carbonyl)4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile exhibited a favorable pharmacokinetic profile in rats. The authors believe that these compounds can provide a promising lead compound that is suitable for the potential treatment of neuropathic pain.
European Journal of Medicinal Chemistry published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Application of 3-Isopropyl-1H-pyrazole-5-carboxylic acid.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics