Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21 was written by Alvarado, Mario;Decara, Juan;Luque, Maria Jesus;Hernandez-Folgado, Laura;Gomez-Canas, Maria;Gomez-Ruiz, Maria;Fernandez-Ruiz, Javier;Elguero, Jose;Jagerovic, Nadine;Serrano, Antonia;Goya, Pilar;de Fonseca, Fernando Rodriguez. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:
Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant-fatty acid amide analogs have been prepared Synthesis of pyrazole analogs was achieved by a two steps simple methodol. via α,β-unsaturated ketones. Carboxamides were obtained in good yields from esters derivatives by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic agents. Some of them showed interesting properties reducing food intake in rats by a mechanism which does not involve the endocannabinoid system. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).
Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics