Moeller, Dorothee et al. published their research in Journal of Medicinal Chemistry in 2014 | CAS: 141032-72-6

Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Synthetic Route of C7H6N2O

Functionally Selective Dopamine D2, D3 Receptor Partial Agonists was written by Moeller, Dorothee;Kling, Ralf C.;Skultety, Marika;Leuner, Kristina;Huebner, Harald;Gmeiner, Peter. And the article was included in Journal of Medicinal Chemistry in 2014.Synthetic Route of C7H6N2O The following contents are mentioned in the article:

Dopamine D2 receptor-promoted activation of Gαo over Gαi may increase synaptic plasticity and thereby might improve neg. symptoms of schizophrenia. Heterocyclic dopamine surrogates comprising a pyrazolo[1,5-a]pyridine moiety were synthesized and investigated for their binding properties when low- to subnanomolar Ki values were determined for D2L, D2S, and D3 receptors. Measurement of [35S]GTPγS incorporation at D2S coexpressed with G-protein subunits indicated significant bias for promotion of Gαo1 over Gαi2 coupling for several test compounds Functionally selective D2S activation was most striking for the carbaldoxime I (Gαo1, pEC50 = 8.87, Emax = 65%; Gαi2, pEC50 = 6.63, Emax = 27%). In contrast, the investigated 1,4-disubstituted aromatic piperazines (1,4-DAPs) behaved as antagonists for β-arrestin-2 recruitment, implying significant ligand bias for G-protein activation over β-arrestin-2 recruitment at D2S receptors. Ligand efficacy and selectivity between D2S and D3 activation were strongly influenced by regiochem. and the nature of functional groups attached to the pyrazolo[1,5-a]pyridine moiety. This study involved multiple reactions and reactants, such as Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6Synthetic Route of C7H6N2O).

Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Synthetic Route of C7H6N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics