Nasveschuk, Christopher G. published the artcileDiscovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2, Name: 1H-Pyrazole-4-boronic acid, the publication is ACS Medicinal Chemistry Letters (2014), 5(4), 378-383, database is CAplus and MEDLINE.
The identification and development of a novel series of small mol. Enhancer of Zeste Homolog 2 (EZH2) inhibitors is described. A concise and modular synthesis enabled the rapid development of structure-activity relationships, which led to the identification of I as a potent, SAM-competitive inhibitor of EZH2 that dose-dependently decreased global H3K27me3 in KARPAS-422 lymphoma cells.
ACS Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Name: 1H-Pyrazole-4-boronic acid.
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Pyrazoles – an overview | ScienceDirect Topics