Bryan, Marian C. published the artcileN-substituted azaindoles as potent inhibitors of Cdc7 kinase, Category: pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2056-2060, database is CAplus and MEDLINE.
Cdc7 kinase is responsible for the initiation and regulation of DNA replication and was proposed as a target for cancer therapy. We have identified a class of Cdc7 inhibitors based on a substituted indole core. Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36). In parallel, quantum mech. conformational anal. helped to rationalize SAR observations, led to a proposal of the preferred binding conformation in the absence of co-crystallog. data, and allowed the design of 7-azaindole 37 as a second lead in this series.
Bioorganic & Medicinal Chemistry Letters published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Category: pyrazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics