A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.
A solution of Pb(OAc)2¡¤3H2O (0.0379 g, 0.1 mM) in water (3 mL) was added to a solutionof H2MPCA (0.0126 g, 0.1 mM) in 6 mL of a 1 : 1 (v : v) EtOH and water and stirred for 1h. The resulting solution was evaporated at room temperature. Colorless crystals of 1(0.0178 g, 78%) suitable for single-crystal X-ray diffraction analysis were obtained after one day.
The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.