Adding a certain compound to certain chemical reactions, such as: 26621-44-3, name is 3-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26621-44-3, 26621-44-3
K2003 (48.9 g, 353.8 mmol) is added to a solution of 3-nitro-1H-pyrazole (20.0 g,176.9 mmol) in THF (200 mL) followed by 2-bromo-ethanol (18.8 mL, 265.3 mmol) and the mixture is heated under reflux for 24 h. After cooling, the mixture is partitioned between water (200 mL) and EtOAc (200 mL). The phases are separated and the aqueous phase is extracted with EtOAc (2 x 200 mL). The combined organic phases aredried (MgSO4), filtered and concentrated in vacuo. The crude residue is purified by trituration from Et20, the solid is collected by filtration and washed with Et20, DCM and Et20 again. The filtrate is concentrated in vacuo and is triturated from Et20. The solids are combined to give the title compound (18.1 g, 64 % yield) as an off-white solid.
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