Pfefferkorn, Jeffrey A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 18 | CAS: 14580-22-4

Bioorganic & Medicinal Chemistry Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Related Products of pyrazoles-derivatives.

Pfefferkorn, Jeffrey A. published the artcileP2Y1 receptor antagonists as novel antithrombotic agents, Related Products of pyrazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(11), 3338-3343, database is CAplus and MEDLINE.

The P2Y1 and P2Y12 purinergic receptors are responsible for mediating ADP (ADP) dependent platelet aggregation. Evidence from P2Y1 knockout studies as well as from nucleotide-based small mol. P2Y1 antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders. Herein, we report the identification and optimization of a series of non-nucleotide P2Y1 antagonists that are potent and orally bioavailable.

Bioorganic & Medicinal Chemistry Letters published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Related Products of pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics