Li, Yingjun published the artcileN-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors, Related Products of pyrazoles-derivatives, the publication is ACS Medicinal Chemistry Letters (2015), 6(5), 543-547, database is CAplus and MEDLINE.
A series of N-(3-ethynyl-2,4-difluorophenyl)sulfonamides were identified as new selective Raf inhibitors. The compounds potently inhibit B-RafV600E with low nanomolar IC50 values and exhibit excellent target specificity in a selectivity profiling investigation against 468 kinases. They strongly suppress proliferation of a panel of human cancer cell lines and patient-derived melanoma cells with B-RafV600E mutation while being significantly less potent to the cells with B-RafWT. The compounds also display favorable pharmacokinetic properties with a preferred example (3s) demonstrating significant in vivo antitumor efficacy in a xenograft mouse model of B-RafV600E mutated Colo205 human colorectal cancer cells, supporting it as a promising lead compound for further anticancer drug discovery.
ACS Medicinal Chemistry Letters published new progress about 1363381-82-1. 1363381-82-1 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Bromide,Ether, name is 5-Bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine, and the molecular formula is C7H6BrN3O, Related Products of pyrazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics