Szymanska, Ewa’s team published research in Chemical Biology & Drug Design in 90 | CAS: 763120-58-7

Szymanska, Ewa published the artcileAryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands, Computed Properties of 763120-58-7, the publication is Chemical Biology & Drug Design (2017), 90(6), 1271-1281, database is CAplus and MEDLINE.

A series of racemic unnatural amino acids was rationally designed on the basis of recently published X-ray structures of the GluA2 LBD with bound phenylalanine-based antagonists. Twelve new diaryl- or aryl/heteroaryl-substituted phenylalanine derivatives were synthesized and evaluated in vitro in radioligand binding assays at native rat ionotropic glutamate receptors. The most interesting compound in this series, (RS)-2-amino-3-(3′-hydroxy-5-(1H-pyrazol-4-yl)-[1,1′-biphenyl]-3-yl)propanoic acid 7e, showed the binding affinity of 4.6 μM for native AMPA receptors and over fourfold lower affinity for kainic acid receptors. Furthermore, 7e was evaluated at recombinant homomeric rat GluA2 and GluA3 receptors. Recently reported X-ray structures 5CBR and 5CBS, representing two distinct antagonist binding modes, were used as templates for mol. docking of the synthesized series. Binding data supported with mol. modeling confirmed that aryl/heteroaryl-substituted phenylalanine analogs effectively bind to AMPA receptors with low micromolar affinity and high selectivity over native NMDA and kainate receptors. These properties make 7e a promising lead for the further development of new AMPA receptor ligands.

Chemical Biology & Drug Design published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C14H28O5S, Computed Properties of 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics