Baraldi, Pier Giovanni’s team published research in Farmaco in 46 | CAS: 890590-91-7

Farmaco published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Product Details of C7H10N2O2.

Baraldi, Pier Giovanni published the artcileSynthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazopyrazole-5-carboxamides. 2, Product Details of C7H10N2O2, the publication is Farmaco (1991), 46(11), 1337-50, database is CAplus and MEDLINE.

A series of 4-diazopyrazole-5-carboxamides were synthesized and their antibacterial activity against a number of Gram-neg. and Gram-pos. strains was tested. Some of the compounds were quite active and the whole set was allowed to further study the SAR of the class. Substituents in position 5 affect Gram-neg. and Gram-pos. activities via bulk and electronic properties resp.; position 3 mostly affects the Gram-neg. activity, while the presence of the charged diazo group in position 4 is crucial for both antibacterial activities.

Farmaco published new progress about 890590-91-7. 890590-91-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid, name is 3-Isopropyl-1H-pyrazole-5-carboxylic acid, and the molecular formula is C7H10N2O2, Product Details of C7H10N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics