Reid, Paul R.’s team published research in Bioorganic & Medicinal Chemistry Letters in 21 | CAS: 763120-58-7

Reid, Paul R. published the artcileDiscovery and optimization of a novel, selective and brain penetrant M₁ positive allosteric modulator (PAM): The development of ML169, an MLPCN probe, Recommanded Product: 1H-Pyrazole-4-boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(9), 2697-2701, database is CAplus and MEDLINE.

This Letter describes a chem. lead optimization campaign directed at VU0108370, a weak M₁ PAM hit with a novel chem. scaffold from a functional HTS screen within the MLPCN. An iterative parallel synthesis approach rapidly established SAR for this series and afforded VU0405652 (ML169) (I), a potent, selective and brain penetrant M₁ PAM with an in vitro profile comparable to the prototypical M₁ PAM, BQCA, but with an improved brain to plasma ratio.

Bioorganic & Medicinal Chemistry Letters published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, Recommanded Product: 1H-Pyrazole-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics