Barraclough, Paul published the artcileInotropic polyazapentalene sulmazole analogs, COA of Formula: C5H7N3O, the publication is Archiv der Pharmazie (Weinheim, Germany) (1992), 325(4), 225-34, database is CAplus and MEDLINE.
Aryl substituted 1H-imidazo[1,2-a]imidazole I, imidazo[2,1-b]thiazole II (X = S), 1,4-dihydroimidazo[4,5-d]imidazole III, and 1(2),4-dihydroimidazo[4,5-c]pyrazoles IV (Y = SOMe, SMe, cyano, CONH2) and V (Z = cyano, CONH2) have been prepared Thus, 2-aminoimidazole reacted with 2-bromo-2′,4′-dimethoxyacetophenone to give II (X = NCH2R1, R1 = 2′,4′-dimethoxybenzoyl) which was treated with Zn in aqueous HOAc to give I in 70% yield. An x-ray crystallog. study confirmed the structure of I and showed this analog to exist as the 1H-tautomer. These heterocycles were evaluated as inotropic agents and analogs IV (Y = SOMe, CONH2) and V (Z = CONH2) displayed inotropic properties which were less potent in vitro, but more potent in vivo, than those of sulmazole. Structure-activity relationships are discussed.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 3553-12-6. 3553-12-6 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Amine,Amide, name is 3-Acetamidopyrazole, and the molecular formula is C5H7N3O, COA of Formula: C5H7N3O.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics