Bebbington, David published the artcileThe discovery of the potent aurora inhibitor MK-0457 (VX-680), HPLC of Formula: 851435-28-4, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3586-3592, database is CAplus and MEDLINE.
The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibitors of cellular proliferation. MK-0457 (I) has been assessed in Phase II clin. trials in patients with treatment-refractory chronic myelogenous leukemia (CML) or Philadelphia chromosome-pos. acute lymphoblastic leukemia (Ph + ALL) containing the T315I mutation.
Bioorganic & Medicinal Chemistry Letters published new progress about 851435-28-4. 851435-28-4 belongs to pyrazoles-derivatives, auxiliary class Imidazole,Pyrimidine,Chloride,Amine, name is 2-Chloro-6-methyl-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine, and the molecular formula is C9H10ClN5, HPLC of Formula: 851435-28-4.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics