Wilde, Richard G. published the artcileACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes, Recommanded Product: 4-Bromo-1-methyl-1H-pyrazol-5-amine, the publication is Bioorganic & Medicinal Chemistry (1996), 4(9), 1493-1513, database is CAplus and MEDLINE.
Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. The most active compounds were thiopyrans I [R1 = pentyl, octyl]. Minor changes in structure had a significant effect in optimization of the biol. activity of this series of compounds
Bioorganic & Medicinal Chemistry published new progress about 105675-85-2. 105675-85-2 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Bromide,Amine, name is 4-Bromo-1-methyl-1H-pyrazol-5-amine, and the molecular formula is C10H9ClN2O, Recommanded Product: 4-Bromo-1-methyl-1H-pyrazol-5-amine.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics