Hosseini, Simin S.’s team published research in Dalton Transactions in 40 | CAS: 763120-58-7

Hosseini, Simin S. published the artcileSynthesis, carbohydrate- and DNA-binding studies of cationic 2,2′:6′,2”-terpyridineplatinum(II) complexes containing N- and S-donor boronic acid ligands, HPLC of Formula: 763120-58-7, the publication is Dalton Transactions (2011), 40(2), 506-513, database is CAplus and MEDLINE.

Platinum(II) complexes [Pt(trpy)L](NO₃)_n (L = 3- or 4-pyridineboronic acid (3- or 4-pyB, resp.), n = 2; HL = 4-mercaptophenylboronic acid (HmpB), n = 1; trpy = 2,2′:6′,2”-terpyridine) and [{Pt(trpy)}₂(μ-pzB)](NO₃)₃ (HpzB = 4-pyrazoleboronic acid) were synthesized and fully characterized by multinuclear (¹H, ¹³C, ¹¹B, and ¹⁹⁵Pt) 1-dimensional- and 2-dimensional-NMR spectroscopy and elemental anal. The triflate derivatives [Pt(trpy)(4-pyB)](OTf)₂ and [{Pt(trpy)}₂(μ-pzB)](OTf)₃ were also prepared, and their mol. structures were confirmed by x-ray crystallog. Variable pH ¹H NMR spectroscopy showed that hydroxylation of the boronic acid group occurs in aqueous solution at pH > 5 and the pK_a values for the complexes were determined In buffered aqueous solution (pH 7.4), the complexes bind strongly to simple diols such as catechol and monosaccharides including D-fructose, D-ribose, D-sorbitol and D-mannitol, as determined by isothermal titration calorimetry (ITC). The equilibrium binding constants for these reactions were determined and were found to exceed those of organic boronic acids such as phenylboronic acid by an order of magnitude or greater, an effect that can be directly attributed to the cationic charge of the complexes. Two-dimensional-NMR methods (HSQC and HMBC) were used to elucidate the structures of the carbohydrate adducts [Pt(trpy)(3-pyB)]·D-fructose·NO₃ and [Pt(trpy)(4-pyB)]·D-fructose·NO₃ in aqueous solution DNA-binding experiments with calf-thymus DNA (CT-DNA) indicate an avid DNA-binding interaction by the mononuclear complexes, as determined using thermal melting methods and ITC, but the behavior of dinuclear [{Pt(trpy)}₂(μ-pzB)](NO₃)₃ is complicated and could not be modeled adequately; higher ionic strength solutions and lower temperatures resulted in a similar DNA binding interaction to the mononuclear complexes. The presence of excess D-fructose did not significantly affect the binding of the platinum(II)-trpy complexes to CT-DNA.

Dalton Transactions published new progress about 763120-58-7. 763120-58-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is 1H-Pyrazole-4-boronic acid, and the molecular formula is C3H5BN2O2, HPLC of Formula: 763120-58-7.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics