Karlsson, Staffan published the artcileFrom Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations, HPLC of Formula: 2057507-56-7, the publication is Organic Process Research & Development (2022), 26(3), 601-615, database is CAplus.
With the first generation medicinal chem. synthesis as a starting point, herein process development of AZD4573, an oncol. drug candidate was described. In addition to improved yields and removal of chromatog. steps, other factors such as availability of starting materials as well as safety of the chem. involved were addressed. With several steps involving volatile, reactive, and non-UV active materials, reaction optimization was facilitated by implementing off-line 1H NMR anal. of crude mixtures Key transformations targeted for process development included a Wolff-Kishner reduction, an iridium-catalyzed borylation, and enzymic resolution of a racemic amino-ester.
Organic Process Research & Development published new progress about 2057507-56-7. 2057507-56-7 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 3-Bromo-5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole, and the molecular formula is C8H11BrN2, HPLC of Formula: 2057507-56-7.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics