Noonan, Jonathan published the artcileIn vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy, Product Details of C8H7N3, the publication is Theranostics (2018), 8(22), 6195-6209, database is CAplus and MEDLINE.
Vascular immune-inflammatory responses play a crucial role in the progression and outcome of atherosclerosis. The ability to assess localized inflammation through detection of specific vascular inflammatory biomarkers would significantly improve cardiovascular risk assessment and management; however, no multi-parameter mol. imaging technologies have been established to date. Here, we report the targeted in vivo imaging of multiple vascular biomarkers using antibody-functionalized nanoparticles and surface-enhanced Raman scattering (SERS). Methods: A series of antibody-functionalized gold nanoprobes (BFNP) were designed containing unique Raman signals in order to detect intercellular adhesion mol. 1 (ICAM-1), vascular cell adhesion mol. 1 (VCAM-1) and P-selectin using SERS. Results: SERS and BFNP were utilized to detect, discriminate and quantify ICAM-1, VCAM-1 and P-selectin in vitro on human endothelial cells and ex vivo in human coronary arteries. Ultimately, non-invasive multiplex imaging of adhesion mols. in a humanized mouse model was demonstrated in vivo following i.v. injection of the nanoprobes. Conclusion: This study demonstrates that multiplexed SERS-based mol. imaging can indicate the status of vascular inflammation in vivo and gives promise for SERS as a clin. imaging technique for cardiovascular disease in the future.
Theranostics published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Product Details of C8H7N3.
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https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics