Borthwick, Jennifer A. published the artcileStructurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening, Synthetic Route of 724710-02-5, the publication is Journal of Medicinal Chemistry (2016), 59(6), 2452-2467, database is CAplus and MEDLINE.
Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a combination of STD-NMR, thermal melt (Tm), and biochem. assays to identify compounds that bound to BCATm, which were subsequently progressed to X-ray crystallog., where a number of exemplars showed significant diversity in their binding modes. The hits identified were supplemented by searching and screening of addnl. analogs, which enabled the gathering of further X-ray data where the original hits had not produced liganded structures. The fragment hits were optimized using structure-based design, with some transfer of information between series, which enabled the identification of ligand efficient lead mols. with micromolar levels of inhibition, cellular activity, and good solubility
Journal of Medicinal Chemistry published new progress about 724710-02-5. 724710-02-5 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Boronic acid and ester,Pyrazole,Boronic Acids,Boronic acid and ester, name is (1H-Pyrazol-5-yl)boronic acid, and the molecular formula is C3H5BN2O2, Synthetic Route of 724710-02-5.
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