Tawil, Bassem F. published the artcileSynthesis of the spermidine alkaloid (±)-N(1)-acetyl-N(1)-deoxymayfoline, SDS of cas: 27412-71-1, the main research area is deoxymayfoline acetyl synthesis; mayfoline acetyldeoxy synthesis.
The total synthesis of the spermidine alkaloid (±)-N(1)-acetyl-N(1)-deoxymayfoline [(±)-I, R = Ac] was achieved by expansion of rings. The 5-membered cyclic compound II was fused with butadiene by intermol. Diels-Alder cycloaddition The resulting 7-phenyl-1,6-diazabicyclo[4.3.0]nona-3,7-dien-9-one was reductively cleaved with Raney-Ni in alc. KOH to afford the mono-cyclic lactam III (R1 = H). This was selectively alkylated in high yields to the cyano derivative III (R1 = CH2CH2CN). Reduction of the nitrile group to the amine derivative went smoothly by use of Adam’s catalyst in the presence of acid. Intramol. transamidation was then accomplished by acid catalysis to furnish the 13-membered diazalactam I (R = H). The synthesis of (±)-I (R = Ac) was completed by the selective acetylation of the more nucleophilic amino group.
Tetrahedron published new progress about deoxymayfoline acetyl synthesis; mayfoline acetyldeoxy synthesis. 27412-71-1 belongs to class pyrazoles-derivatives, name is 5-Phenyl-1H-pyrazol-3(2H)-one, and the molecular formula is C9H8N2O, SDS of cas: 27412-71-1.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics