Hecht, Sidney M. published the artcileActivation of cytokinins, Quality Control of 54385-49-8, the main research area is cytokinin analog structure activity; plant hormone cytokinin analog.
A number of cytokinin analogs containing modifications in the heterocyclic moiety were prepared These compounds were tested for activity as cytokinins and anticytokinins in the tobacco bioassay and the results were used to determine whether any position(s) of the heterocyclic nucleus of cytokinins may require derivatization as part of an over-all activation process. 3-Substituted 4-alkylaminopyrazolo[3,4-d]pyrimidines and 4-alkylaminopyrrolo[2,3-d]pyrimidines, have carbon rather than nitrogen atoms at positions 3 and 5, resp., (analogous to position 7 in purines) and would be predicted to be metabolically stable at these positions. The finding that these compounds had cytokinin activity suggested that modification at the metabolically stable position, and by extension at position 7 in cytokinin analogs which are purines, is not a prerequisite for the expression of cytokinin activity. Similar consideration of other heterocyclic analogs which have cytokinin activity suggests that the active form of a cytokinin can be the exogenous compound itself. Certain structural analogs of cytokinins were found to inhibit the growth of tobacco callus promoted by 6-(3-methyl-2-butenylamino)purine. These compounds were studied as potential cytokinin antagonists, i.e. having activity analogous to the 7-alkylamino-3-methylpyrazolo[4,3-d]pyrimidines (Hecht, S. M., Bock, R. M., Schmitz, R. Y., Skoog, F., and Leonard, N. J. 1971; Skoog, F., Schmitz, R. Y., Hecht, S. M., and Bock, R. M. 1973). The activity of these compounds is discussed and criteria are proposed to distinguish between those species which are specific anticytokinins and those which otherwise inhibit growth.
Journal of Biological Chemistry published new progress about Structure-activity relationship. 54385-49-8 belongs to class pyrazoles-derivatives, name is 5-Amino-1H-pyrazole-3,4-dicarbonitrile, and the molecular formula is C5H3N5, Quality Control of 54385-49-8.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics