On September 30, 1993, Hichour, M.; Mary, F.; Marzin, C.; Naji, M.; Tarrago, G. published an article.Category: pyrazoles-derivatives The title of the article was N-Alkylation of pyrazolones with OH-protection. And the article contained the following:
The synthesis of biheterocyclic compound I containing two pyrazolone sub-units is described. The oxygen atom of 3-carbethoxypyrazol-5-one is first protected with dihydropyran to obtain selective alkylation with 1-3-dibromopropane. The experimental process involved the reaction of Ethyl 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate(cas: 153597-59-2).Category: pyrazoles-derivatives
The Article related to pyrazolonecarboxylate protection alkylation dibromopropane, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics