Kendall, Jackie D.; O’Connor, Patrick D.; Marshall, Andrew J.; Frederick, Raphael; Marshall, Elaine S.; Lill, Claire L.; Lee, Woo-Jeong; Kolekar, Sharada; Chao, Mindy; Malik, Alisha; Yu, Shuqiao; Chaussade, Claire; Buchanan, Christina; Rewcastle, Gordon W.; Baguley, Bruce C.; Flanagan, Jack U.; Jamieson, Stephen M. F.; Denny, William A.; Shepherd, Peter R. published an article in 2012, the title of the article was Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.Recommanded Product: 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid And the article contains the following content:
A novel series of pyrazolo[1,5-a]pyridines were prepared as PI3 kinase inhibitors, and their selectivity for the p110α isoform over the other Class Ia PI3 kinases was demonstrated. The SAR around the pyrazolo[1,5-a]pyridine ring system was investigated, and N’-[(5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene]-N,2-dimethyl-5-nitrobenzenesulfonic acid hydrazide was shown to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model. The experimental process involved the reaction of 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid(cas: 143803-93-4).Recommanded Product: 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid
The Article related to pyrazolopyrazinylmethylene benzenesulfonylhydrazine preparation pi3 kinase inhibitor anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 4-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics