On October 15, 2015, Aguilar Izquierdo, Nuria; Buil Albero, Maria Antonia; Connolly, Stephen; Eastwood, Paul Robert; Roberts, Richard Spurring; Sevilla Gomez, Sara; Vidal Juan, Bernat published a patent.Product Details of 314021-93-7 The title of the patent was TRPA1 channel antagonists as therapeutic agents. And the patent contained the following:
The invention relates to compounds I, [G1= CH, N; G2= C(Ra), N; G3= C, N; G4= C, N; G5= C(Rb), N(Rc), N, O, S; G6= C(Rb), N(Rc), N, O, S; G7= C(Rb), N(Rc), N, O, S; Q= monocyclic or bicyclic C6-C14 aryl, monocyclic or bicyclic 5-14 membered heteroaryl ring, halogen, etc.; R1= H, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C6-C14 aryl, CH2Ph; R2= H, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C6-C14 aryl, CH2Ph; R3= H, F; R4= H, F; Ra= H, C1-C4 alkyl, halogen, C1-C4 alkoxy, etc., Rb= H, C1-C4 alkyl, halogen, C1-C4 alkoxy, etc., Rc= H, C1-C4 alkyl, C1-C4 haloalkyl, C3-C7 cycloalkyl], and the preparation and use for the treatment of a pathol. condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism. The experimental process involved the reaction of 1-Methyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol(cas: 314021-93-7).Product Details of 314021-93-7
The Article related to trpa1 channel antagonist preparation, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Product Details of 314021-93-7
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics