On October 14, 2013, Jung, Chan Seong; Kim, Dong Jin; Park, Gi Deok; Kim, Yun Gyeong; Pyo, Jeong In; Kim, Hyeon Tae; Hwang, On Yu; Azam, Sharif Mohammed Shafioul; Song, Chi Man; Kim, Yeong Su published a patent.Application of 85426-79-5 The title of the patent was Preparation of pyrazolopyrimidine derivatives for inhibiting nitric oxide generation. And the patent contained the following:
Disclosed are pyrazolopyrimidine derivatives, e.g., I [R1 = H, (un)substituted alkyl, (un)substituted aryl, etc.; R2 = H, halo, (un)substituted alkoxy, etc.; X1 = H, halo or (un)substituted aryl; or pharmaceutically acceptable salts thereof]. For example, compound II was prepared by following general procedure: reaction of 4-chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine with an amine (1.1 equiv) [dioxane, reflux temperature, 8 h]. Compound II [NR2 = piperidn-1-ylethylamino] showed 102±6% inhibition at 20 μM for NO generation. Title compounds are claimed useful for the treatment of Parkinson disease, Alzheimer disease, Hungtinton disease, etc. The experimental process involved the reaction of 4-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine(cas: 85426-79-5).Application of 85426-79-5
The Article related to pyrazolopyrimidine preparation nitric oxide generation inhibition, cerebral nerve disease treatment pyrazolopyrimidine nitric oxide generation inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 85426-79-5
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics