Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. Recommanded Product: 4-Nitro-1H-pyrazole.
Liu, Yong-zheng;Guo, Heng-jie research published 《 Solubility determination and crystallization thermodynamics of an intermediate in different organic solvents》, the research content is summarized as follows. This study reported the solid-liquid equilibrium solubility of 4-nitropyrazole at the temperature ranging 288.15 K to 328.15 K in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 1-pentanol, isoamyl alc., acetonitrile, acetone, Me acetate, Et acetate, THF and water, resp. All the experiments were performed with the gravimetric method under the ambient pressure of 0.1 MPa. At the temperature ranging from 288.15 K to 328.15 K, 4-nitropyrazole in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 1-pentanol, isoamyl alc., acetonitrile, acetone, Me acetate, Et acetate, THF and water exhibited the mole fraction solubility values of 0.109034-0.365964, 0.101321-0.310165, 0.087146-0.312564, 0.048152-0.238024, 0.079024-0.282653, 0.054890-0.247235, 0.071382-0.275687, 0.062864-0.21521, 0.039062-0.135087, 0.038140-0.058187, 0.007271-0.027222, 0.004829-026068, 0.004126-0.021975 and 0.002174-0.015095, resp. The acquired solubility data of 4-nitropyrazole in the selected solvents was correlated with the modified Apelblat equation, λh equation, the ideal equation, as well as the polynomial empirical equation. Next, the correlated values of the four equations were significantly consistent with the experiment values, and the polynomial empirical equation yielded more effective correlated results than other equations. In addition, the solvent effect on 4-nitropyrazole solubility was investigated with Kamlet-Taft parameters. Moreover, to clarify the sequence of solubility in a range of solvents, the mol. modeling studies were conducted. Activity coefficient was to access the solute-solvent mol. interactions. Furthermore, the thermodn. properties exhibited by 4-nitropyrazole (i.e., standard dissolution enthalpy (ΔdisHo), standard dissolution entropy (ΔdisSo) and standard dissolution Gibbs free energy (ΔdisGo)) in the selected solvents were characterized and then discussed from the experiment data. Besides, ΔdisHo, ΔdisSo and ΔdisGo at mean temperature in different pure solvents reached 22.40 kJ·mol-1-38.07 kJ·mol-1, 58.21 J·K-1·mol-1-81.10 J·K-1·mol-1 and 4.20 kJ·mol-1-13.13 kJ·mol-1, resp. As revealed from the result, 4-nitropyrazole in solvents selected showed a non-spontaneous and entropy-driven dissolution The present study could present the fundamental data to sep. 4-nitropyrazole.
Recommanded Product: 4-Nitro-1H-pyrazole, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., 2075-46-9.
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics