Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 2075-46-9, formula is C3H3N3O2, Name is 4-Nitro-1H-pyrazole. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. HPLC of Formula: 2075-46-9.
Liu, Wen-dong;Li, Yong-xiang;Cao, Duan-lin;Li, Zi-yang research published 《 Solubility and thermodynamic properties of an energetic intermediate in four binary solvents (water + n-butanol, n-pentanol, isobutanol and isoamyl alcohol)》, the research content is summarized as follows. The solubility of 4-nitropyrazole (4-NP) in four different binary solvents (i.e., water + n-butanol, water + n-pentanol, water + isobutanol, and water + isoamyl alc.) was firstly determined by a gravimetric method within a temperature range of 288.15 K to 328.15 K at atm. pressure (P = 0.1 MPa). The exptl. results indicated that the solubility of 4-NP in selected binary solvents increases with the increasing temperature and decreases with the rising water mass-fraction ranging. Besides, the (solid + liquid) equilibrium values in the studied solvents were correlated based on the modified Apelblat equation, Jouyban-Acree model, CNIBS/R-K model, and Wilson model. Moreover, all of the 324 exptl. values were used to correlate the parameters of the Wilson model, and the correlated results were superior to the other three models by comparing the average 104RMSD and R2. The average root-mean-square deviation (104RMSD) values were 1.87, 31.83, 6.04, and 1.18, resp. In addition, Hansen solubility parameters were employed to provide a reasonable illustration for the solubility order of 4-NP in the 4 binary mixed solvents, and the order of 4-NP solubility in each binary solvent mixture was the result of the combined effects of hydrogen bonding, dispersion, and polarity. Furthermore, the Wilson model was applied to calculate the thermodn. properties of 4-NP including mixing enthalpy, mixing entropy, and mixing free Gibbs energy in the studied binary solvent mixtures at a given temperature It is easy to understand that dissolution is an exothermic process from the results. Solid-liquid surface tension (γ) and surface entropy factor (f) of 4-NP were estimated by using the exptl. solubility data, and the results showed that γ and f increase with the increasing mass-fraction of water content in the binary mixed solvent and decrease with the increasing temperature The exptl. solubility values, model parameters, and thermodn. properties of 4-NP in different mixed solvents will provide the necessary support for its preparation, crystallization process, and further theor. studies.
2075-46-9, 4-Nitro-1H-pyrazole, also known as 4-Nitropyrazole, is a useful research compound. Its molecular formula is C3H3N3O2 and its molecular weight is 113.08 g/mol. The purity is usually 95%.
4-Nitropyrazole, is a building block for the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can be used for the synthesis of highly selective, brain-penetrant aminopyrazole LRRK2 Inhibitor, as a potentially viable treatment for Parkinson’s disease., HPLC of Formula: 2075-46-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics