Category: pyrazoles-derivativesOn November 15, 2019 ,《Synthesis, physicochemical and antimicrobial properties of cardanol-derived quaternary ammonium compounds (QACs) with heterocyclic polar head》 appeared in Journal of Molecular Liquids. The author of the article were Ma, Jingyi; Liu, Na; Huang, Mengen; Wang, Limin; Han, Jianwei; Qian, Hui; Che, Fei. The article conveys some information:
As new biomass derived raw material, cardanol has attracted the attention of numerous academic and industrial groups due to its renewability and unique structural features. In this work, seven cardanol-derived quaternary ammonium compounds (QACs) were synthesized with their physicochem. properties and antimicrobial ability evaluated. The surface tension was measured in aqueous medium by the platinum ring method, 2b has the optimal surface activities, which is considerably better than commercialized QAC product cetyltrimethylammonium bromide. Both broth dilution method and agar dilution method were used to obtain the MIC and MBC values of the targeted QACs. 1a, 1b, 2b inhibit the tested bacterial at a concentration of 32μg/mL. SEM (SEM) results intuitively showed that the QACs could interact with the bacterial cell membrane, for disrupting the integrity of the membrane. Meanwhile, it was found that the antimicrobial activity depended not only on the alkyl chain length, but also on the CMC value. To sum, seven cardanol-derived QACs were synthesized easily, which showed excellent surface activities and antimicrobial activity, as a promising alternative to the existing fossil fuel derived cationic surfactants and antiseptics. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Category: pyrazoles-derivatives)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Category: pyrazoles-derivatives
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics