In 1989,Coe, Paul L.; Cook, Michael I. published 《Reactions of tetrafluoroethene oligomers. Part XII. Cycloaddition reactions of 3,3,4,4,4-pentafluoro-2-(pentafluoroethyl)-2-(trifluoromethyl)diazobutane. A novel synthesis of pyrazoles》.Journal of Fluorine Chemistry published the findings.Computed Properties of C5H6N2O2 The information in the text is summarized as follows:
The title diazoalkane I reacts smoothly with a variety of electron-deficient alkenes to give, unexpectedly, pyrazole derivatives Thus, reaction with Me or Et propenoate affords the Me and Et esters of pyrazole-3-carboxylic acid. Reaction with di-Et maleate yields 3,4-bis(ethoxycarbonyl)pyrazole, and di-Me maleate gives the di-Me ester II. Treatment of I with propenonitrile afforded 3-cyanopyrazole, and with propenoic acid pyrazole-3-carboxylic acid was obtained. In all of these reactions two side products were isolated, namely perfluoro(3-methylpent-2-ene) and 3H-3-trifluoromethyldecafluoropentane. A mechanistic rationale for these unusual and potentially useful reactions is given. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Computed Properties of C5H6N2O2)
Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Computed Properties of C5H6N2O2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics