Davies, Huw M. L.’s team published research in Synthetic Communications in 1992 | CAS: 15366-34-4

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Application of 15366-34-4

《Convenient synthesis of vinyldiazomethanes from α-diazo-β-keto esters and related systems》 was written by Davies, Huw M. L.; Hougland, Paul W.; Cantrell, William R. Jr.. Application of 15366-34-4This research focused onvinyldiazomethane; diazoketo ester reduction; diazohydroxy ester preparation dehydration. The article conveys some information:

A series of vinyldiazomethanes, including, RCH:CHCN2CO2R1 (R = H, R1 = Me, CMe3; R = Me, EtS, R1 = Et, Me) and CH2:CHCN2PO(OEt)2, were readily prepared by sodium borohydride reduction of α-diazo-β-keto esters, e.g., RCH2COCN2CO2R1 and MeCOCN2PO(OEt)2, followed by phosphorus oxychloride induced dehydration of the resulting α-diazo-β-hydroxy esters. In the experiment, the researchers used Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Application of 15366-34-4)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Application of 15366-34-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics